Sperm isn’t just DNA — it’s epigenetic memory. In Xenopus, we show sperm H2AK119ub1 guides paternal chromatin remodeling in the embryo. Removing it before fertilization disrupts development via misregulated gene expression

A ten-year study carried out by 36 french research centers, including the NEMO team, shows that high-dose vitamin D supplementation reduces multiple sclerosis progression at an early stage.

Le CR2TI se mobilise au sein du mouvement Stand up for Sciences face aux menaces contre les institutions scientifiques afin de défendre la liberté académique et de soutenir les chercheurs et chercheurses dont le travail est menacé, notamment aux Etats-Unis, en Argentine, et ailleurs.

A l'initiative de l'association Femmes et Mathématiques et de l'association Femmes et Sciences, le CR2TI a participé à l'Opération Coquelicots le 8 mars 2025.

The NEMO team will meet patients on March 28th to discuss research and advances in multiple sclerosis. Come and meet us!

Many thanks to our generous donators!

Neuroinflammatory diseases, in particular multiple sclerosis, still raise many questions about their origins and mechanisms. The NeuroDIP research program, led by Dr. Nicolas Vince at the CR2TI, has set itself the goal of developing an innovative approach, combining several multidisciplinary approaches, to better predict and diagnose these pathologies.

Autoimmune liver diseases (AILD) involve dysregulated CD4 T cell responses against liver self-antigens, but the link between these autoreactive T cells and liver pathclogy is unclear. Read the results of our study published in Nature Communications and discover how Circulating autoreactive CD4 T cells in AILD are imprinted by chronic antigen exposure, promoting liver inflammation and representing a potential target for AILD biomarkers and therapies. PMID: 39880819

Congratulations to Dr. Amédée Renand, whose project has been selected for the 2025 AFEF award!

Sepsis induces immune changes that persist for months after the disease has resolved. Read the results of our study published in Nature Immunology and discover how sepsis survivors had a lower cumulative incidence of cancer and how a chemokine network released by sepsis-resident macrophages promotes tissue-resident T cells. PMID: 38684922

Questions about the BEST-Fluid Trial? Christophe Masset, Lucile Figueres and colleagues at ITUN and CR2TI are in correspondence in The Lancet with the authors of the clinical study and the use of balanced crystalloid solutions to prevent kidney damage (DGF) after transplantation. Although the results are promising, more research is needed to confirm their efficacy, especially in light of new organ preservation techniques such as machine perfusion. To further reduce DGF, several factors have been identified: minimizing organ damage during surgery, using advanced preservation methods, optimizing anti-rejection medications, and potentially using new treatments for both donors and organs.

Respiratory microbial dysbiosis is associated with acute respiratory distress syndrome (ARDS) and hospital-acquired pneumonia (HAP) in critically ill patients. Read the results of the validated robust respiratory microbiome signatures associated with ARDS and HAP, published in Nature Med. Such signatures may help to identify promising targets for microbiome therapeutic modulation in critically ill patient. PMID: 37957375