Team 5 : Neuroinflammation, mechanisms, therapeutic options (NEMO)
Research program
Team 5 focuses on the immune mechanisms underlying autoimmune demyelinating diseases of the central nervous system, studying the pathophysiology and treatment of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Our current research program aims at improving MS management, deciphering the immunopthology of MS linked to genetics. The developed research makes use of national biobanks (OFSEP) and collaborations with reputed national and international laboratories (IMSGC).We particularly focus our fundamental research on CD8+ T cells and B cells in MS pathology, deciphering which subpopulations are involved and how they can be specifically targeted. In our research program, studies on antibody specificity linked to microbiota dysbiosis are developed. We also study the role of glial cell and antigen reactivity. Translational, genetic and clinical studies on MS and NMO complete the NEMO panel of research. We have access to and exhaustive biobank of MS patient samples (serum, saliva, LCS, stools, colon and brain sections, DNA collection: RefGenSEP). Animal models of MS (mice and rats) are also used to decipher pathological mechanisms and to test potential treatment as proof of concept.
Clinicians
Research assistants
Postdoctoral fellows
PhD students
Selected publications
Progressive Multifocal Leukoencephalopathy Incidence and Risk Stratification Among Natalizumab Users in France. JAMA Neurol. 2019 Sep 3. PMID: 31479149
Comparative effectiveness of Teriflunomide vs dimethyl fumarate in multiple sclerosis. Neurology. 2019 Jul 12;93(7):10.1212/WNL.0000000000007938–e646. PMID: 31300547An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8 + T cells involved in multiple sclerosis. J Autoimmun. 2018 Mar;88:61–74. PMID: 29054368
Transcript analysis of laser capture microdissected white matter astrocytes and higher phenol sulfotransferase 1A1 expression during autoimmune neuroinflammation. J Neuroinflammation. 2015 Jul 4;12(1):871. PMID: 26141738