Team 1 : Mononuclear phagocytes, Immunopathology, Immunovirology
Team 1 leaders: Dr. Elise Chiffoleau & Pr. Régis Josien
1. The team aims to explore MNP heterogeneity and functions in immune-mediated diseases in both human tissues and animal models in order to better understand their role and discover new relevant therapeutic targets. Recently, the team contributed to the understanding of the molecular basis of immunoregulatory MNP functions in transplantation (Cell Metabolism, 2019), anti-tumor immunity (Cancer Cell 2019, Blood adv. 2017, Front Immunol 2020) and inflammatory bowel diseases (Mucosal Immunol 2016, Cell 2019). The current projects focus on deciphering MNP heterogeneity and molecular mechanisms of their immunoregulatory function in the context of cancer, inflammatory diseases and infection to better understand the mechanisms underlying disease progression and develop novel tools for screening diagnostic and therapeutic strategies.
2. The second axis aims to understand the cellular and molecular mechanisms of the persistent human viruses-host interactions in immunocompromised hosts and the impact on innate and adaptive immune responses. The team described CMV and BKPyV interactions with dendritic cells (Cheneau et al, JID 2018 ; Sikorski M et al 2020, Plos Pathogens 2021) and investigated BKV capsid evolution and its relationship to the host humoral response (McIlroy, Viruses 2020). The team now aims to decipher intra-tissular CMV and BKV/immune/stromal cells interactions, clarify the role of both BKPyV genetic evolution and host genetic polymorphism in viral pathogenesis, and describe changes in the composition of the human virome in link with immune dysfunction.
Research program
Team 1 projects are dedicated to Mononuclear Phagocytes (MNP), Immuno-pathology and Immuno-virology. Two major axes of research are developed :1. The team aims to explore MNP heterogeneity and functions in immune-mediated diseases in both human tissues and animal models in order to better understand their role and discover new relevant therapeutic targets. Recently, the team contributed to the understanding of the molecular basis of immunoregulatory MNP functions in transplantation (Cell Metabolism, 2019), anti-tumor immunity (Cancer Cell 2019, Blood adv. 2017, Front Immunol 2020) and inflammatory bowel diseases (Mucosal Immunol 2016, Cell 2019). The current projects focus on deciphering MNP heterogeneity and molecular mechanisms of their immunoregulatory function in the context of cancer, inflammatory diseases and infection to better understand the mechanisms underlying disease progression and develop novel tools for screening diagnostic and therapeutic strategies.
2. The second axis aims to understand the cellular and molecular mechanisms of the persistent human viruses-host interactions in immunocompromised hosts and the impact on innate and adaptive immune responses. The team described CMV and BKPyV interactions with dendritic cells (Cheneau et al, JID 2018 ; Sikorski M et al 2020, Plos Pathogens 2021) and investigated BKV capsid evolution and its relationship to the host humoral response (McIlroy, Viruses 2020). The team now aims to decipher intra-tissular CMV and BKV/immune/stromal cells interactions, clarify the role of both BKPyV genetic evolution and host genetic polymorphism in viral pathogenesis, and describe changes in the composition of the human virome in link with immune dysfunction.
Research assistants
Gaëlle BERIOU - IH
Cécile BRAUDEAU - IHP
Lucas BRUSSELLE - TC
Justine CHEVREUIL - TH
Flora COULON - AI
Aurélie FANTOU - AHU
Aurélie JOUSSAUME - TCH
Camille LECUROUX - IH
Emmanuel MERIEAU - AI
Cécile PELTIER - TR
Mathieu ROUEL - IE
Cécile BRAUDEAU - IHP
Lucas BRUSSELLE - TC
Justine CHEVREUIL - TH
Flora COULON - AI
Aurélie FANTOU - AHU
Aurélie JOUSSAUME - TCH
Camille LECUROUX - IH
Emmanuel MERIEAU - AI
Cécile PELTIER - TR
Mathieu ROUEL - IE
Postdoctoral fellows
PhD students
Selected publications
Characterization of Rat ILCs Reveals ILC2 as the Dominant Intestinal Subset. Front Immunol. 2020 Feb 19;11:700. PMID: 32140157
Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis. Cell Metab. 2019 Dec 3;30(6):1075-1090.e8. PMID: 31801055
Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation. J Immunol. 2017 May;198(9):3671–3678. PMID: 28356382
Cell-surface C-type lectin-like receptor CLEC-1 dampens dendritic cell activation and downstream Th17 responses. Blood Adv. 2017 Mar 28;1(9):557–568. PMID: 29296975
Mis à jour le 09 February 2022 par Sarah BRUNEAU.