SEMINAR ; Dr Céline DELALOY - “Rewiring immunity: IL-2 signaling in B cell fate and function “

Céline Delaloy obtained her PhD in Genetics from UPMC in 2006. Her research focuses on the molecular and cellular mechanisms that regulate gene expression and cell fate decisions in pathophysiological models of human disease. Following postdoctoral training at the Gladstone Institutes (UCSF), where she investigated epigenetic regulation of neuronal differentiation, she joined INSERM in 2013. At the U1236 MOBIDIC lab, her team studies how B cells integrate external signals to drive plasma cell differentiation and how they are reprogrammed toward immunosuppressive functions in inflammatory settings. Her work combines experimental models and single-cell approaches to investigate B cell plasticity. She also develops in vitro models of human B cell differentiation to explore key signaling pathways and transcriptional regulators involved in B cell homeostasis and their dysregulation in autoimmunity and cancer. Her talk will explore IL-2 signaling using a novel mouse model lacking IL2RB signaling specifically in mature B cells, revealing IL-2’s intrinsic role in promoting plasma cell differentiation and modulating B cell functions in inflammatory conditions. By expanding the focus beyond T cells, this work uncovers new layers of immune regulation with broad implications for disease and therapy.