SEMINAR ; Dr Jérôme CARTAILLER - Brain function under general anesthesia : from neural signals to computational digital twins

I am currently chargé de recherche at INSERM within the MASCOT unit U942 (Cardiovascular MArkers in Stressed COndiTions), and I also hold a complementary activity as a technological consultant for the Assistance Publique-Hôpitaux de Paris. My primary field of research concerns the mathematical modeling of physiological functions under general anesthesia, with an initial focus on brain functions and a progressive extension to cardiovascular dynamics. My scientific objective is to develop the different building blocks required to characterize individual physiological trajectories during general anesthesia, from digital biomarker extraction to the construction of actionable models, in order to identify patient-specific vulnerabilities such as cardiovascular risk, cognitive decline, or mortality at an early stage. This work relies on the analysis of physiological signals and their translation into mechanistic/statistical/AI-based models, with a strong emphasis on integrating heterogeneous, real-world data streams for personalized inference.