SEMINAR ; Dr Irène ZORZAN - Modelling the human placenta-endometrium niche in vitro

The placenta is essential for the exchange of nutrients and gases between mother and foetus, and its proper development is critical for pregnancy success. To overcome the lack of physiologically relevant models, we established a tissue-engineered system that recapitulates the receptive endometrium and supports early postimplantation development of human embryos and stem cell–derived blastoids. This platform enables advanced trophoblast differentiation, including trophoblast plate and villus formation, providing a powerful tool to study the molecular mechanisms regulating the placenta–endometrium niche.